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Nicolas Molinari MISTEA, UMR
729 Service DIM Service de Biostatistique, Epidémiologie,
Santé Publique et Information Médicale (BESPIM) Phone: +(33) 4 99 61 24 28
/ +(33) 4 66 68 34 03 |
Research interests
- Biostatistics
- Clinical research
- Health geography
Former and current
students (PhD)
- Grégory Marin (2010-..)
- Jules Mbougua (2009-12)
- Chadi Ghariani (2007-2010)
- Marie Denis (2007-2010)
- Nadège Dossat (2005-2009)
- Christelle Reynès (2004-2007)
- Christophe Dematteï (2003-2006)
Teaching
Master 2 Biostatistique http://www.agro-montpellier.fr/um2/um1/masterbiostatistique/
Master 1 Biostatistique http://www.iurc.montp.inserm.fr/biostat/documents/FICHE_UE_BIOSTAT1.pdf
Events
Statistical Innovations In Clinical Trials http://www.biopharma2009-sfds.fr/
COBRA http://cobra.bespim.fr/
AFSSAPS http://www.sante-sports.gouv.fr/fichiers/bo/2008/08-12/ste_20080012_0100_0065.pdf
Publications
69. Muller L, Jaber S, Molinari N, Favier
L, Larche J, Motte G, Lazarovici S, Jacques L, Alonso S, Leone M, Constantin JM, Allaouchiche B, Suehs C, Lefrant JY, Group A.
(2012), Fluid management and risk factors for renal dysfunction in patients
with severe sepsis and/or septic shock, Crit Care.,
16(1):R34
68. De Jong A., Jung B., Chanques G., Jaber S. & Molinari
N., Obesity and mortality in critically ill patients: another case of
Simpson’s paradox?, CHEST, letter, to
appear.
67. Ky C.-L., Vergnet A., Molinari N., Fauvel
C. & Bonhomme F. (2012), Fitness on early life stages in F1 interspecific
hybrids between Dicentrarchus
labrax and D. punctatus, Aquatic Living
Resoures, 25, 67-75.
66. Nougaret S.,
Rouanet P., Molinari N., Pierredon
M.A., Bibeau F., Azria D., Lemanski C., Assenat E., Duffour J., Ychou M.,
Reinhold C. & Gallix B. (2012), MR Volumetric Measurement of Low
Rectal Cancer Helps Predict Tumor Response and Outcome after Combined
Chemotherapy and Radiation Therapy, Radiology,
263, 2, 409-18.
65. Gris J.C., Bouvier S., Molinari
N., Galanaud J.P., Cochery-Nouvellon
E., Mercier E., Fabbro-Peray P., Balducchi
J.P., Marès P., Quéré I.
& Dauzat M. (2012), Comparative incidence of a
first thrombotic event in purely obstetric antiphospholipid
syndrome with pregnancy loss: the NOH-APS observational study, BLOOD, 119, 11, 2624-32.
64. Daien C., Fabre S., Rittore C., Soler S., Daïen V., Tejedor G., Cadart D., Molinari
N., Daurès J.P., Jorgensen C. & Touitou I., TGF beta1 polymorphisms are candidate
predictors of the clinical response to rituximab in
Rheumatoid Arthritis, Joint Bone Spine,
to appear.
63. Sotto A,
Richard JL, Messad N, Molinari N, Jourdan N, Schuldiner S, Sultan A, Carrière
C, Canivet B, Landraud L, Lina G & Lavigne JP. (2012), Distinguishing colonization from infection with
Staphylococcus aureus in diabetic foot ulcers with
miniaturized oligonucleotide arrays: a French multicentre
study. Diabetes Care, 35(3):617-623.
62. Gris J.C., Chauleur C., Molinari
N., Mares P., Fabbro-Peray P., Quere I., Lefrant J.Y., Haddad B.
& Dauzat M. (2011), Addition of enoxaparin to aspirin for the secondary prevention of
placental vascular complications in women with severe pre-eclampsia:
the pilot randomised controlled NOH-PE trial, Thrombosis and Haemostasis,
10, 6, 1053-1061.
61. Laurent C., Kouanfack C., Laborde-Balen G., Aghokeng A.F., Mbougua J.B.,
Boyer S., Carrieri M.P., Mben
J.M., Dontsop M., Kazé S., Molinari N., Bourgeois A., Mpoudi-Ngolé E. (2011), Spire B., Koulla-Shiro
S., Delaporte E.; for the Stratall
ANRS 12110/ESTHER study group, Monitoring of HIV viral loads, CD4 cell counts,
and clinical assessments versus clinical monitoring alone for antiretroviral
therapy in rural district hospitals in Cameroon (Stratall
ANRS 12110/ESTHER): a randomised non-inferiority
trial, Lancet Infection Disease, 11,
11, 825-833.
60. Pulcini C., Dellamonica J., Bernardin G., Molinari
N., Sotto A. (2011), Impact of an intervention designed to improve the
documentation of the reassessment of antibiotic therapies in an intensive care
unit, Médecine Maladies Infectieuses,
41, 10, 546-552.
59. Denis M. & Molinari
N. (2011), Free-knots splines with RJMCMC for logistics models
and threshold selection, JP Journal of
Biostatistics, 5, 1, 17-34.
58. Roy P., Truntzer C., Maucourt-Boulch D., Jouve T. & Molinari N. (2011), Protein mass spectra data analysis for clinical
biomarker discovery: a global review, Briefings in Bioinformatics, 12, 2, 176-86.
57. Muller L., Toumi M., Bousquet P.J., Riu-Poulenc B., Louart
G., Candela D., Zoric L., Suehs C., de La Coussaye J.E., Molinari N.,
Lefrant J.Y., in the AzuRéa Group (2011), An increase in aortic blood flow
after an infusion of 100 ml of colloid over one minute can predict fluid
responsiveness: the mini-fluid challenge study, Anesthesiology, 115, 3,
541-547.
56. Gouzi F., Préfaut
C., Abdellaoui A., Vuillemin
A., Molinari N., Caris
G. & Hayot M. (2011), Evidence of an early
physical reduction in COPD patients, Archives
of Physical Medicine and Rehabilitation, 92, 10, 1611-1617.
55. Abdellaoui A., Préfaut C., Gouzi F., Couillard A.,
Coisy-Quivy M., Hugon G., Molinari N., Lafontaine T., Jonquet O.,
Laoudj-Chenivesse D. & Hayot M. (2011), Skeletal muscle effects of
electrostimulation after COPD exacerbation: a pilot study, Eur
Respir J., 38, 4,
781-788.
54. Bornard L., Dellamonica,
Hyvernat H., Girard-Pipau F., Molinari N., Sotto A., Roger P.M.,
Bernardin G. & Pulcini C. (2011),
Impact of an assisted reassessment of antibiotic therapies on the quality
of prescriptions in a medical intensive
care unit, Médecine Maladies Infectieuses, 41, 9, 480-485.
53. Laurent C., Tchatchueng-Mbougua J.B., Ngom Guèye N.F., Etard J.F.,
Diouf A., Landman R., Molinari N., Girard P.M., Sow P.S., Ndoye I., Delaporte
E., for the ANRS 1215/1290 Study Group (2011), Long-term effectiveness and
safety of didanosine combined with lamivudine and efavirenz or nevirapine in
antiretroviral-naive patients: a 9-year cohort study in Senegal, Tropical
Medicine & International Health, 16, 2, 217-222.
52. Pulcini C., Williams F., Molinari N., Davey
P. & Nathwani D. (2011), Junior doctors’ knowledge and perceptions of
antibiotic resistance and prescribing: a survey in France and Scotland, Clinical
Microbiology and Infection, 17, 1, 80-87.
51. Mineur L., Sabatier R.,
Kirscher S., Plat F., Goubely Y. & Molinari N. (2011), Are we
turning to more than a first line treatment of metastatic colorectal cancer
with high dose irinotecan?: A monocentric institution safety analysis of 46
patients, Gastroenterol Clin Biol, 35(2):125-131.
50. Denis M. & Molinari
N. (2010), Free knot splines with RJMCMC in survival data analysis, Communications
in Statistics - Theory and Methods, 39, 14, 2617–2629.
49. Maïnassara HB, Molinari N.,
Dematteï C. & Fabbro-Peray P. (2010), The relative risk of spatial cluster
occurrence and spatiotemporal evolution of meningococcal disease, Niger
2002-2008, Geospatial Health, 5(1):90-131.
48. Chiron R., Vachier I., Khanbabaee G., Molinari N., Varrin M.,
Godard P. & Chanez P. (2010), Impact of rhinitis on
asthma control in children: association with FeNO, Journal of Asthma, 47(6), 604-608.
47. Minchella A., Lechiche C., Poujol H., Molinari
N. & Sotto A. (2010), Investigating
clinical practice in antibiotic therapy for acute community-acquired pneumonia,
Med Mal Infect., 40, 2, 100-105.
46. Tchatchueng-Mbougua J., Laurent C., Kouanfack C., Bourgeois A.,
Ciaffi L., Calmy A., Gwet H., Koulla-Shiro S., Ducos J., Mpoudi-Ngolé E., Molinari
N. & Delaporte E. (2010), Hepatotoxicity and effectiveness
of a Nevirapine-based antiretroviral therapy in HIV-infected patients with or
without viral hepatitis B or C infection in Cameroon, BMC Public Health,
10, 1, 105.
45. Law M., Chuh A., Molinari N. & Lee A.
(2010), An Investigation of the Association Between Diet and Occurrence of
Acne: A Rational Approach from a Traditional Chinese Medicine Perspective, Clinical
and Experimental Dermatology, 35(1):31-5.
44. Law M.P.M., Chuh A.A.T., Lee A. & Molinari
N. (2010), Acne prevalence and beyond: acne disability and its predictive
factors among Chinese late adolescents in Hong Kong, Clinical and
Experimental Dermatology, 35(1):16-21.
43. Ghariani C. & Molinari N. (2009),
Mann-Kendall test with missing data, Far East
Journal of Theoretical Statistics, 28, 1, 9-19.
42. Tramini P., Molinari N., Tentscher M., Demattei C.
& Schulte AG. (2009), Association
between caries experience and body mass index in 12-year-old French children, Caries
Research, 43(6):468-73.
41. Le Guédard-Méreuze S., Vaché C., Molinari N.,
Vaudaine J., Clautres M., Roux A.F. & Tuffery-Giraud S. (2009), Sequence contexts that
determine the pathogenicity of base substitutions at position +3 of donor
splice sites, Human Mutation, 30(9):1329-39.
40. Frédéric M.Y., Clot F., Blanchard A., Dhaenens
M.C., Lesca G., Cif L., Durr A., Vidailhet M., Sablonniere B., Calender A.,
Martinez M., Molinari N., Brice A., Claustres M., Tuffery S. &
Collod-Beroud G. (2009), The p.Asp216His TOR1A allele effect is not found in
the French population, Movement Disorders. 24, 6, 919-921.
39. Reynes C., Sabatier R., Molinari N. &
Lehmann S. (2008), A new genetic algorithm in proteomics: feature selection for
SELDI-TOF data, Computational Statistics and Data Analysis, 52,
4380-4394.
38. Jacot W., Lhermitte L., Dossat N., Pujol J.L., Molinari
N., Daurès J.P., Maudelonde T., Mangé A. & Solassol J. (2008), Serum proteomic profiling
of lung cancer in high-risk groups and determination of clinical outcomes, Journal
of Thoracic Oncology, 3, 8, 840-850.
37. Pourel N., Santelmo N., Hilgers W., Meunier J.P.,
Naafa N., Mineur L., Rabanit A., Soutif A., Hirschi S., Molinari N.
& Reboul F. (2008), Concurrent Cisplatin/Etoposide plus 5-field
3D-conformal radiotherapy followed by surgery for stages IIB (superior sulcus
T3N0)/III Non-Small-Cell lung cancer yields a high rate of pathologic complete
response, European Journal of Cardiovascular and Thoracic Surgery, 33,
5,829-836.
36. Mange A., Desmetz C., Bellet V., Molinari N.,
Maudelonde T., Solassol J. (2008), Proteomic profile determination of autosomal
aneuploidies by mass spectrometry on amniotic fluids, Proteome Science,
11, 6(1), 1.
35. Molinari N. (2007), Free knot splines
for supervised classification, Journal of Classification, 24, 2,
221-234.
34. Dematteï, C. & Molinari,
N. (2007), P-value
calculations for multiple temporal cluster detection, Les
Comptes Rendus de l'Académie des Sciences - Mathématiques, 344, p.
697-701.
33. Dematteï, C., Molinari, N. & Daurès,
J.P. (2007), Arbirarily
shaped multiple spatial cluster detection for case event data, Computational Statistics and Data
Analysis, 51, p. 3931-3945.
32. Reynès C., Roche S., Tiers L., Sabatier R., Jouin P.,
Molinari N. & Lehman S. (2007), Comparison between surface and bead
based matrix-assisted laser desorption/ionization profiling technologies using
a single bioinformatics method, Clinical Proteomics, 2 (3-4), 1542-6416
(Print), 1559-0275 (Online).
31. Whittom S., Dauvilliers Y., Pennestri M.H., Vercauteren F., Molinari N.,
Petit D. & Montplaisir J. (2007), Age-at-onset in restless legs syndrome :
a clinical and polysomnographic study, Sleep Medicine, 9(1):54-59.
30. Dossat, N., Mangé, A., Solassol,
J., Jacquot, W., Lhermitte, L., Maudelonde, T., Daurès, J.P. & Molinari,
N. (2007), Comparaison
of supervised classification methods for protein profiling in cancer diagnosis,
Cancer Informatic, 3, 295-305.
29. Chuchana, P., Marchand, D., Nugoli, N., Rodriguez,
C., Molinari, N. & Garcia-Sanz, L. (2007), An adaptation of the LMS
method to determine expression variations in profiling data, Nucleic Acids
Research, 1-10, doi : 10.1093/nar/gkm093.
28. Reynès, C., Sabatier, R. & Molinari, N.
(2006), Choice of
B-splines with free parameters in the flexible
discriminant analysis context, Computational
Statistics and Data Analysis, 51, p. 1765-1778.
27. Demattei, C. & Molinari, N. (2006), Multiple temporal
cluster detection test using exponential inequalities, Far East Journal
of Theoretical Statistics,
129, 2, 231-244.
26. Demattei, C., Molinari, N. & Daurès,
J.P. (2006), SPATCLUS:
An R package for arbitrarily shaped multiple spatial cluster detection for case
event data, Computer
Methods and Programs in Biomedicine, 84, 1, 42-49.
25. Hazard, L., Betin, M. & Molinari, N.
(2006), Correlated
response in plant height and heading date to selection in perennial ryegrass
populations, Agronomy
Journal, 98, 1384-1391.
24. Demattei, C., Zawar, B., Lee, A., Chuh, A. & Molinari,
N. (2006), Spatial-temporal case clustering in children with
Gianotti-Crosti syndrome. Systematic analysis led to the identification of a
mini-epidemic, Eur J
Pediatr Dermatol, 16, 159-64.
23. Molinari, N. (2005), A U-statistic test in competing risk model, Les
Comptes Rendus de l'Académie des Sciences - Mathématiques, 341, 5,
317-322.
22. Bessaoud, F., Daurès, J.P. & Molinari, N.
(2005), Free knot splines for logistic models and threshold selection, Computer Methods and Programs in
Biomedicine, 77, 1-9.
21. Chuh, A., Zawar, V., Lee, A. & Molinari, N.
(2005), Regression analysis on temporal case clustering in Gianotti-Crosti
syndrome, Int Pediatr,
20, 157-161.
20. Colbach, C., Molinari, N., Meynard, J.M.
& Messéan, A. (2005), Spatial aspects of gene flow between rapeseed
varieties and volunteers, Agronomy
for Sustainable Development, 25, 355-368.
19. Chuh, A., Molinari, N., Sciallis, G.,
Harman, M., Akdeniz, S. & Nanda, A. (2005), Temporal
case clustering in pityriasis rosea - A regression analysis on 1379 patients in
Minnesota, Kuwait, and Diyarbakir, Turkey, Archives of Dermatology, 141, 767-771.
18. Molinari, N., Durand, J.F. & Sabatier, R. (2004), Bounded
optimal knots for regression splines, Computational
Statistics and Data Analysis, 45(2), p. 159-178.
17. Morel, J., Roch Bras, F., Molinari, N.,
Sany, J., Eliaou, J.F. & Combe, B. (2004), HLA-DMA*0103 and HLA-DMB*0104
alleles, as novel prognostic factors in rheumatoid arthritis, Annals of Rheumatic Diseases,
63(12), 1581-1586.
16. Colbach, N., Molinari, N. & Clermont, C.
(2004), Sensitivity analyses for a model simulating demography and genotype
evolutions with time. Application to GeneSys modelling gene
flow between rapeseed varieties and volunteers, Ecological Modelling, 179, 91-113.
15. Roux, A.F., Pallares, N., Vielle, A., Faugere, V.,
Templin, C., Leprevost, D., Artieres, F., Lina, G., Molinari, N.,
Blanchet, P., Mondain, M. & Claustres, M. (2004), Molecular epidemiology of
DFNB1 deafness in France, BMC
Medical Genetics, 5, 5.
14. Abraham, C., Cornillon, P.A., Matzner-Lober, E.
& Molinari, N. (2003), Unsupervised
curve clustering using B-splines, Scandinavian
Journal of Statistics, 30, 581-595.
13. Molinari, N. & Daurès, J.P. (2003), In vitro fertilization
modellization with immune patients, Communications
in Statistics - Theory and Methods, 32, 9, 1859-1870.
12. Bonaldi, C., Daurès, J.P. & Molinari, N.
(2003), Comments on 'Multiple temporal cluster detection', Biometrics, 59 (3), 734.
11. Dauvilliers, Y., Carlander, B., Molinari, N.,
Desautels, A., Okun, M., Tafti, M., Montplaisir, J., Mignot, E. & Billiard,
M. (2003), Month of birth as a risk factor for narcolepsy, SLEEP, 26 (6), 663-665.
10. Molinari, N., Koné-Paut, I., Manna, R., Demaille, J., Daurès, J.P.
& Touitou, I. (2003), Identification of an autosomal recessive mode of
inheritance in paediatric Behçet's families by segragation analysis, American Journal of Medical Genetics,122A
(2), 115-118.
9. Chuh, A., Lee, A. & Molinari, N. (2003),
Case clustering in
Pityriasis Rosea - a multi-center epidemiological study in primary care
settings in Hong Kong, Archive
of Dermatology, 139 (4), 489-493.
8. Molinari, N., Morena, M., Cristol, J.P. & Daurès, J.P. (2002),
Free knot splines for biochemical data, Computer
Methods and Programs in Biomedicine, 67, 163-167.
7. Molinari, N., Bonaldi, C. & Daurès, J.P. (2001), Multiple temporal
cluster detection, Biometrics,
57, 178-184.
6. Molinari, N., Daurès, J.P. & Durand, J.F. (2001), Regression splines for
threshold selection in survival data analysis, Statistics in Medicine, 20, 237-247.
5. Dauvilliers, Y., Montplaisir, J., Molinari, N.,
Carlander, B., Ondze, B., Besset, A. & Billiard, M. (2001), Age at onset of
narcolepsy in two large populations of patients in France and
4. Ait El Mkadem, S., Lautier, C., Macari, F., Molinari,
N., Lefèbvre, P., Renard, E., Gris, J.C., Cros, G., Daurès, J.P., Bringer,
J., White, M.F. & Grigorescu, F. (2001), Role of allelic variants Gly972Arg
of IRS-1 and Gly1057Asp of IRS-
3. Cattan, D., Notarnicola, C., Molinari, N.
& Touitou, I. (2000), Inflammatory bowel disease in non-Ashkenazi Jews with
familial Mediterranean fever, Lancet,
355 (9201), 378-379.
2. Touitou, I., Magne, X., Molinari,
N. Navarro, A., Le Quellec, A., Picco, P., Seri, M., Ozen, S., Bakkaloglu, A., Karaduman, A., Granier, J.M., Demaille, J.,
& Koné-Paut, I. (2000), MEFV mutations in Behçet's disease, Human Mutation, 16 (3),
271-272.
1. Durand, J.F., Molinari, N. & Sabatier,
R. (1998), Simple and Multiple Regression Splines with Bounded Optmal Knots,
6th Conference of the International Federation of Classification Societes
(Ifcs-98,